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PHGDH was associated with recurrent copy number gains in breast cancer, and its expression was elevated in 70% of estrogen receptor (ER)-negative breast cancers, indicating that certain breast cancers are dependent on the increased flux of the serine pathway resulting from PHGDH overexpression [52]

Wiederhold, N

Combination therapies One of the most effective approaches to overcome resistance is the rational combination of KRASi with agents that target complementary nodes within the signalling network or immune microenvironment (online supplemental table S3)

doi: 10.1007/s10495-009-0341-y 105 RegitzC.Marie DulingL.WenzelU

discovered that the addition of a sulfhydryl group to water-soluble N -alkyl( o -nitrostyryl)pyridinium ions, leads to the formation of N -hydroxy indole pyridinium ions (Fig

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