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J Cell Biochem [Internet]

Free cystine enters cells via the cystine-glutamate antiporter xCT, while plasma glutathione-disulphide may be the main source of cystine throughout the body (175)

In Erastin-induced ferroptosis, the expression of lysosome-associated membrane protein 2a (LAMP2a) is increased, which promotes heat shock protein 90 (HSP90)-dependent autophagy, which in turn mediates the degradation of GPX4[67]

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Hypomorph mutations or knockdown of many cohesin genes (SMC1, SMC3, RAD21/SCC1, STAG2) are synthetic lethal with PARPi olaparib which are attributed to the overlapping role of cohesin and PARP1/2 in preventing replication fork collapse (Liu et al, 2018