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Int J Mol Sci 21(4):1415 Liu X, Yang R, Bai W et al (2020) Involvement of amylin B-H2S-connexin 43 signaling pathway in vascular dysfunction and enhanced ischemia-reperfusion-induced myocardial injury in diabetic rats

Results: Volunteers ingesting kefir containing ME-3 exhibited the following: a) -16% in oxidized LDL-cholesterol (reduces cardiovascular disease risks) b) -20% in 8-isoprostanes (reduction in free radical damage) c) 10% increase in HDL-cholesterol (not shown on graph) d) 18% increase in paraoxonase enzyme activity (PON1) which regulates detoxification of pesticides and provides antioxidant activity (not on graph) e) 10% decline in triglycerides (not shown on graph) Study #2: Title: Antioxidative probiotic fermented goats milk decreases oxidative stress-mediated atherogenicity in human subjects Journal: British Journal of Nutrition

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It stimulates natural growth hormone production and secretion

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First efforts should be through food, and then supplementation, which offers a reliable path to fill in the gaps