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Previous research has shown that chromatin remodeling by the SWI/SNF factor ARID1A can deplete GSH and increase ROS levels by facilitating NRF2-mediated transcription of SLC7A11

The classical redox pathways including WNT/-catenin, PI3K/AKT, NRF2, and p53 can respond to oxidant or antioxidant signals and significantly regulate gene transcription (Ma et al., 2018), but its effects on PI3K/AKT, NRF2, and other pathways are not consistent

Bone scan: Used if the doctor thinks there might be cancer or long-term bone problems Electrocardiogram (ECG) and ECHO (echocardiogram): These tests are done if the doctor thinks the heart might be causing the pain