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Isoniazid (INH) and rifampicin (RFP) used in combination are the first-line anti-TB regimen and metabolized in the liver accompanied by liver toxicity with large consumption of intracellular GSH, leading lipid peroxidation and hepatocyte death [152]

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[13],[14],[15],[16],[17] It has been used at a low dose of 250 mg twice a day for at least 3 months for the treatment of melasma and found to be effective

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