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References 1.Mahoney-Sanchez L, Belaidi AA, Bush AI, Ayton S

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The observed effects in maximal respiration and reserve capacity most likely occur due to increased glycolysis and consequent augmented flux of pyruvate into the Krebs cycle

Lipid peroxidation and ferroptosis would therefore follow from an accumulation of lipid ROS

4.4 Systemic sclerosis As a consequence of dysfunctional differentiation of fibroblasts to myofibroblasts and excessive deposition of extracellular matrix, systemic sclerosis (SSC) is a rare fibrotic autoimmune disease that leads to skin fibrosis (83)

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