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Alexandria J Med 54:287293 Kang KA, Zhang R, Kim GY et al (2012) Epigenetic changes induced by oxidative stress in colorectal cancer cells: methylation of tumor suppressor RUNX3

Diversion of 3PG out of glycolysis brings proliferative advantages for cancer cells

Response: CMS internally evaluates drugs each quarter to determine whether each is a single-source drug or biological (as defined in section 1847A(c)(6)(D) of the Act) or multiple source drug (as defined in section 1847A(c)(6)(C) of the Act)