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It also provides new insights into developing convenient, efficient, and safe local delivery systems, which may lead to clinical applications

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Also, AC influences the immune response by promoting macrophage polarization toward the M1 phenotype, which is associated with antitumor effects

doi: 10.1016/j.bbrc.2020.01.066

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How these variations impact systemic BA pools and the immune landscape of tumors, particularly those within the hepatobiliary-pancreatic system, and potentially extending to extra-intestinal sites where preliminary associations with BA exposure have been noted (190), needs to be clarified