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Beyond classical antioxidant signaling, GSH interfaces with additional pathways, including Hippo-Yes1 associated transcriptional regulator (YAP1) signaling to regulate GPX4 and SLC7A11 expression, 159,160 mechanistic target of rapamycin kinase (mTOR) signaling to influence GPX4 protein synthesis through cysteine metabolism, 161 and NF-B signaling to restrain inflammation-associated ROS production 162

Each of the eight points supports the next, the way a building distributes its weight across its frame

In combination with chemotherapy, FMD enhanced immunosurveillance and antitumor immune cytotoxicity mediated by CD8+ T cells (59)

Liu X, Simpson JA, Brunt KR, Ward CA, Hall SRR, Kinobe RT, et al