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Big data: historic advances and emerging trends in biomedical research

In 2003, Burke and co-workers synthesized 4-(2-aminoethyl)amino-1,8-dimethylimidazo(1,2- a )quinoxaline (BMS-345541, 81 , Figure 19 ) that was a selective IKK inhibitor (IKK IC 50 /IKK IC 50 = 13.3) via binding to the allosteric site of IKK [35]