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This is largely due to the difficulty in controlling confounding variables such as age, sex, psychiatric comorbidities, and the concomitant use of other medications, which limits the reproducibility and generalizability of findings ( As SSRIs represent the primary class of antidepressants currently in use, the main biological markers studied to date are components of the serotonergic neurotransmission system, including synthetic enzymes, transporters, receptors, and metabolic enzymes for this neurotransmitter (Veenstra-VanderWeele et al., 2000)

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J Biol Chem 281(26):1801518024 Kanzaki H, Shinohara F, Kajiya M, Kodama T (2013) The Keap1/Nrf2 protein axis plays a role in osteoclast differentiation by regulating intracellular reactive oxygen species signaling

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10.1002/pro.401

This effect was prevented by the simultaneous application of L-arginine and NaBPC157