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For procedures in which complications are catastrophic, including TJA, counseling should prioritize discontinuation of nonessential injectable biologics before surgery, explicit documentation of exposure, and heightened vigilance for early wound complications

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(2024) exhibited some concerns regarding the randomization process, raising questions about allocation concealment or baseline imbalances

The study was not a robust randomised, placebo-controlled pain trial and cannot establish treatment of any particular pain condition

One key molecular marker to target is ABCB5