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In parallel, esculin exerts significant anti-inflammatory effects by downregulating pro-inflammatory cytokines, such as TNF-, IL-1, and IL-6, largely through suppression of NF-B and Toll-like receptor signaling pathways 15,16,17

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In a dysbiotic gut, elevated beta-glucuronidase levels promote excessive estrogen reabsorption, contributing to estrogen dominance

The discovery of B-cell lymphoma 2 (BCL2) family proteins further emphasized the importance of mitochondria in controlling apoptosis, linking these organelles to cancer cell survival and therapy resistance