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Berk M, Williams LJ, Jacka FN, ONeil A, Pasco JA, Moylan S, et al

To overcome these possible limitations several strategies have been developed, such as amino acids substitution with residues mimicry, termini protection or introduction of chemical modifications aimed at stabilizing their active conformation and increasing cellular permeability (119, 121)

Geng P, Zhang Y, Liu X et al (2017) Automethylation of protein arginine methyltransferase 7 and its impact on breast cancer progression

So I think that in addition to the drug discovery studies, it's important to develop also biomarker programs with both fluid biomarkers, but also imaging biomarkers to be able to identify the patient populations that will benefit from such treatment

doi: 10.2174/1573399813666170705161039 115 VuralHArmutcuFAkyolOWeiskirchenR