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In terms of GDP change (dollar), the proportional change between 2004 data, which is the oldest data at the provincial level, and 2017 data is taken as the independent variable

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1997 May;144(1):62-9

Extensive preclinical and clinical data suggest that elevated blood pressure and its associated cardiovascular risks are largely due to the interaction between genetic and environmental factors [7,8,9,10,11]

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This landmark study demonstrated that control of asthma using sputum eosinophil numbers to titre ICS use as an adjunct to symptoms and lung function produced better disease control and less overall corticosteroid use