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Metabolic vulnerabilities of metastasizing cancer cells

Concurrently, dysfunctional insulin signaling depletes cellular NAD + levels, further diminishing sirtuin activity and exacerbating mitochondrial dysfunction (Zaltieri et al., 2015

Suramin, a century-old drug used to treat African sleeping sickness and river blindness, can effectively inhibit SARS-CoV-2 polymerase activity with at least 20-fold more activity than RDV-3Pi in biochemical assays and inhibits viral replication in vitro 141

Keep at temperatures between 5C 25C

doi: 10.1016/j.solmat.2023.112289

Both peptides activate similar pathways, but subtle differences in receptor affinity may influence results for specific applications