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Parkin ubiquitinates outer mitochondrial membrane proteins, including voltage-dependent anion channel 1 (VDAC1) and mitofusins (Mfn1 and Mfn2), thereby initiating mitophagy

By inducing a temperature above 38 degrees Celsius (fever), simple seizures occur first, followed by prolonged seizures (lasting more than 15 minutes), which create a predisposition for temporal lobe epilepsy (TLE) [1]

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Of those that influence gene expression, micro RNAs ( miRNAs ) have been the most studied thus far