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10.1093/bbb/zbac043 43 IshmuratovG

however, their reaction kinetics are slow and irreversible 9

The greater production of GSH by astrocytes seems to be dependent on the preferential activation of transcription factor Nrf2 in astrocytes, which leads to a more efficient GSH synthesis and higher GSH content in astrocytes than in neurons [108]

Silymarin (SILY) is a polyphenolic antioxidant complex which is derived from the fruit and seeds of the milk-thistle plant known as Silybum marianum

Thanks to the extensive knowledge of the biochemical pathways and molecular mechanisms engaged in PYO production, it is possible to target specific genes, either to knock them out or to enhance their expression

In IBD, depletion of SCFA-producing bacteriaparticularly butyrate producerscorrelates with increased neutrophil infiltration and NET formation, thereby accelerating disease progression (90)