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In tolerance assay, at 42 h after the end of conditioning regimen, shorter preconvulsive latencies than in healthy (non-diazepam conditioned) mice following isoniazid (800 mg/kg i.p.) (as hallmark of tolerance) were observed if diazepam (5.0 mg/kg i.p.) was again given acutely to mice previously conditioned with diazepam alone (use of picrotoxin 3.0 mg/kg i.p., as convulsant, with acute application of diazepam in previously diazepam conditioned mice did not lead to tolerance hallmark)

Growth hormone, released primarily during deep sleep, is a key driver of neural repair

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During M2 macrophage polarization, the IL-4/STAT6 signaling pathway upregulates YY1, leading to the formation of a liquid-liquid phase separation (LLPS) structure

In addition, there is now emerging evidence that dysregulation of the intestinal barrier can affect distant organs such as the bone