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For example, one of the main characteristics of Parkinsons disease is defective PINK/PARKIN-mediated mitophagy

Microglial ferroptosis has been shown to amplify neurotoxicity by releasing pro-inflammatory mediators (such as TNF- and IL-1), and ferroptosis-related genes including ACSL4 and ALOX15 are highly enriched in microglia within PVL lesions

In the glucose-alanine cycle, this reduction does not occur

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109,170 However, the side effects associated with targeting - and -secretases arise because these enzymes have a wide range of substrates that are vital in other physiological processes

For example, many peptides function as hormones in the body