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b , Distances between Cys46 and its catalytic partners Gln81/Trp136 were monitored in the MD simulation of GPX4 R152H , as compared to GPX4 R152R

This balance influences numerous redox-regulated cellular processes, including the modulation of signaling pathways, post-translational modifications such as protein glutathionylation, activation of transcription factors like Nrf2 and NF-B, and the regulation of cell fate decisions such as proliferation or apoptosis [38]

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