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The mixtures containing inhibitors 1 - 5 were incubated for 6 h and for 30 min for treatments with 6 - 8 at room temperature

The possible carcinogenic mechanisms involve an increase in oxidative stress, that may cause oxidative DNA damage, interfere with DNA repair systems, deregulate growth control mechanisms, and modify DNA methylation patterns ( Living in volcanic areas represents a further risk factor as some of the highest incidences of thyroid cancer are registered in volcanic regions ( Many heavy metals (As, Cd, Cr, Hg, and Pb) have never been tested yet as potential human thyroid carcinogens

The capsule format eliminates the need for calibrated transfer tools making it easier to include the peptide in some studies

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Decellularised nucleus pulposus as a potential biologic scaffold for disc tissue engineering