oral vs injection b12 Vitamin Injections vs. Supplements: Which Do You Actually Need? Vitamin B12 Shots: My Experience

Severe allergic reactions or anaphylaxis can also occur with cyanocobalamin

So when theres a deficiency of these vitamins, the body doesnt use homocysteine as it should, which results in a buildup of this amino acid

Because the body only absorbs the amount of B12 that it needs and flushes the rest out in your urine, it's nearly impossible to build up a toxic level of Vitamin B12, even when taking a high-dose supplement

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acid-reducing medicines such as PPIs, H2RAs) can cause a lack of absorption of Vitamin B12 in the body, leading to a deficiency