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Although the N-isopropyl derivative (called taltrimide) is available for commercial purposes, it is not permitted for therapeutic use because its anticonvulsive effect has been experimental in animal models, not in clinical studies

1A , B, and C Effect of Dihexa on spatial learning in the water maze

Glucose-6-phosphate is very important for the creation of ribose-5-phosphate (needed for DNA) and NADPH (also known as NADP) 4

Disruption of the BBB or blood-spinal cord barrier (BSCB) is one of the features of ALS

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Recent imaging studies reveal that BBB breakdown and glymphatic system impairment associated with gliosis occur early in aging, particularly in the hippocampus, and are exacerbated in mild cognitive impairment, correlating with pericyte injury (Montagne et al., 2015)