3209-A ENGINEERED MESENCHYMAL STEM CELL-DERIVED EXOSOMES PROMOTE MACROPHAGE EFFEROCYTOSIS VIA ADAM9/MERTK AXIS IN ACUTE-ON-CHRONIC LIVER FAILURE Junyi Wang 1 , Zhihui Li 2 , Shibo Meng 3 , Junfeng Chen 1 , Bingliang Lin 3 and Jing Zhang 4 , (1)The Third Affiliated Hospital of Sun Yat-Sen University, (2)Sun Yat-Sen University, (3)The Third Affiliated Hospital, Sun Yat-Sen University, (4)Department of Infectious Diseases, Third Affiliated Hospital of Sun Yat-Sen University Background: Acute-on-Chronic liver failure is a disease with a high mortality rate, the only cure currently available is liver transplantation.Our previous study showed that intravenous injection of mesenchymal stem cells could improve survival rate of acute-on-chronic liver failure patients, and expressed higher levels of Mertk, which could promote macrophage phagocytosis of apoptotic cells and reduced the occurrence of secondary necrosis in the efferocytosis .Mertk can be cleaved by a cell membrane protein ADAM9 and subsequently loses its biological activity.MiR-126 is an upstream molecule of ADAM9 that can inhibit its generation.In this study,we aim to load miR-126 into exosomes of mesenchymal stem cells by electroporation as engineered exosomes,then apply it to the treatment of acute-on-chronic cell model and explore the mechanism
Amelanotic melanoma Amelanotic melanoma lesions appear as enlarging pink to red macules, papules, or nodules with well- or ill-defined borders
Curcumin-supplemented KI mice showed reduced mHTT aggregation and upregulated mRNA expression of striatal DARPP-32 and dopamine receptor D1, which were accompanied by behavioral recovery, particularly in rearing deficits (Hickey et al., 2012)
In fact, the way we treat the rest of our body has a major impact on our brain's ability to grow, change, and continue developing
Click Here Overdose (OD) happens when a toxic amount of a drug, or combination of drugs overwhelms the body
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