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Lip Discoloration: Causes, Types, and Treatment That Works What Caused These Multiple Hyperpigmented Macules of the Mouth? Labial Melanotic Macule On Lip Labial Macules: Dark Spots on the Lip Dermatology Advisor Treatment of labial melanotic macules on the lip. These are benign spots that appear on the lips for no apparent reason. The causes are mostly genetic, but similar spots can appear in smokers, after Pigmented lesions of the oral cavity: An Update PMC
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