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HRW upregulates antioxidant enzymes (HO-1, SOD-1) while suppressing pro-inflammatory cytokines (IL-1, IL-6, TNF-) and NF-B activation (38)

J Hazard Mater 393:122384 Lpez-Valverde N, Lpez-Valverde A, Montero J, Rodrguez C, Macedo de Sousa B, Aragoneses JM (2023) Antioxidant, anti-inflammatory and antimicrobial activity of natural products in periodontal disease: a comprehensive review

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These compounds directly or indirectly exhibit antioxidant properties which can sustain the intracellular redox status and these activities protect the healthy cells from reactive oxygen species induced oxidative damage