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doi: 10.3390/ijms20205225 10 GupteAMumperRJ

Changes in SOD activity were not observed in the whole stimulated saliva of CD patients

hence, direct cell or tissue application is common in laboratory research

Their short lifespan and segmented nucleus set them apart [54]

Although quercetin and metformin are found to possess antidiabetic activity in unison and their mechanism is found to be unclear, the combination therapy exhibits synergistic effects

Therefore, fully personalized Gut-on-a-Chip testing should be prioritized for settings in which patient-specific intestinal first-pass metabolism is expected to highly influence safety, efficacy, or clinical development decisions