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Analysis of effectiveness of treatment (main outcome) at the three monitoring points Intention-to-treat and per-protocol analyses will both be performed, as is recommended for non-inferiority studies [38]

In C2C12 myotubes, NNMT inhibitor treatment produces concentration-dependent increases in NADH levels (50% higher at 30 M) and reduces NAD+/NADH ratios by 25-40%