This is the reality of cutting-edge therapeutics: The data evolves, and those of us on the leading edge have to make informed decisions based on incomplete but promising evidence
While surgical denervation does not adversely affect expression of Mist1 (Fig 3B and E), muscarinic stimulation is sufficient to increase MIST1 in human cultures and suggests that although not required for acinar cell identity, acetylcholine/muscarinic signaling may act as a positive regulator of the secretory program
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