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The likely mechanisms include both peptides anti-inflammatory action, improved cerebral blood flow from angiogenesis, direct neuroprotective signaling, and support for nerve growth factor production

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Because AOD-9604 does not activate growth hormone receptors and functions through an entirely separate beta-3 adrenergic pathway, it does not trigger cortisol release

However, increasing oral supplement doses (within safe limits) while awaiting medical review is generally considered safe, as B12 has very low toxicity and excess is excreted through the kidneys

J Gastrointest Surg 1998;2:436-42