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However, the addition of Fer-1 restored GPX 4 and SLC 7 A 11 expression levels, which were otherwise inhibited by herceptin, and reversed the herceptin-induced increase in ACSL 4 expression and increased mitochondrial ROS and iron levels, protecting H9c2 cardiomyocytes from herceptin-induced cardiomyocyte injury and ferroptosis (84)

(B) In the presence of pro-oxidative stimuli, dimerized GSTT1 binds to p38 and MK2, promoting the activity of these kinases, which in turn elevate the expression of GSTT1