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The inactivation of Exportin-mediated export of OXS2 and hence nuclear accumulation of OXS2, and the autoactivation of its own gene, are all caused by oxidative stress and followed by the activation of a stress-induced pathway (Robert and David, 2004)

In addition to RTECs, ferroptosis can be seen in almost all types of renal cells in DKD

Then as a result of the free radical chain reaction, the skin produced lipid, protein, DNA, and other free radicals

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