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Furthermore, the literature is replete with insufficient concepts, such as inflammatory depression or immune-mediated depression, and the classification of depression on the basis of these flawed concepts further obfuscates the interpretation and understanding of the NIMETOX pathways in MDD

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For example, when the environmental conditions change, and the intestinal permeability increases (leaky gut), systemic translocation of a part of GM, which is LPS, directly activates the TLR4 receptor

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