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LATE DISSEMINATED LYME If symptoms have been present for greater than one year, or if you have received prior therapy for Lyme disease, then other potentially contributing causes such as co-infections, mold, autonomic dysfunction, mitochondrial dysfunction, mast cell activation, and autoimmunity should be explored as part of the differential diagnosis

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Impaired mitophagy and fragmented mitochondrial morphology are emerging as novel contributors to neuronal vulnerability in AD (Figure 3)

Successively, the gut microbiota is highly sensitive to environmental signals, receiving, integrating and responding to the information not only from the different organs of the body, but also from external influences like diet, physical activity, psychological and physical stress, sleep restrictions, socioeconomic status, drugs, antibiotics, exposure to pets, noise, and temperature [63]

Human plasminogen is highly susceptible to peroxynitrite inactivation