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Conclusion and future perspectives Although many questions remain unanswered, it is becoming increasingly clear that oxidative stress-induced damage to the TM is related to glaucoma, which may inspire futher studies to find better and more stable antioxidants and better models with which to elucidate the mechanisms involved, and to determine whether in vitro findings can translate into in vivo observations

Interestingly, our data show that the microbial processing of glucose inhibits the expression of gst-4, as 2-DG treated bacteria did not confer this same effect

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Concomitantly, targeted therapies directed at this mechanism hold promise as novel and prospective treatment approaches, thereby offering more precise and effective therapeutic strategies for patients with WD

Potential Benefits & Side Effects Observations from clinical trials and published literature