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Experimental perturbations in central-carbon metabolism that increase the KG/succinate ratio can enhance the activity of KG-dependent dioxygenases and bias embryonic stem (ES) cells and certain models of cancer towards differentiation 1,2,3

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however, MitoQ, as an efficient mtROS scavenger, reduced the generation of mtROS and effectively inhibited the phosphorylation of Drp1, indicating that Drp1 is regulated by mtROS