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Similarly, as discussed previously, auranofin has demonstrated the ability to enhance T cell anti-tumor immunity in preclinical models and holds strong potential for repurposing as a cancer therapeutic, given its established use in rheumatoid arthritis (134)

Surface plasmon resonance analyses provide direct evidence of melittins interaction with these critical upstream signaling molecules, with dissociation constants of 4.6 10 -6 M (IKK ), 1.34 10 -9 M (IKK ), and 1.01 10 -9 M (p50), highlighting its specificity and potency (90, 91)

These gene variants can manipulate the immune system, metabolic enzymes, or mitochondrial function to accelerate AMD progression through micro-cellular inflammation and increased oxidative stress in the retina

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