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In vivo experiments further demonstrated that Irisin-loaded bone marrow mesenchymal stem cell-derived exosomes significantly inhibited activation of the YAP/EGR1/ACSL4 signaling pathway in the brains of middle cerebral artery occlusion (MCAO) mice, suppressed ferroptosis and lipid peroxidation, thereby mitigating ischemic brain injury ( In vitro experiments further confirmed that FGF21 protected HT22 cells from OGD/R-induced oxidative stress and ferroptosis, thereby attenuating neuronal injury (Zhao et al., 2025c)

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Resistance to experimental tumorigenesis in cells of a longlived mammal, the naked molerat ( Heterocephalus glaber )

Cohen-Melamed E, Nyska A, Pollack A, Madar Z

doi: 10.3390/ijms222111484, 20

[DOI] [PubMed] [Google Scholar] 237.Di Domenico F