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Description

The depletion of tryptophan in the TME impairs effector T cell function, while kynurenine degradation products can suppress tumor immunity by inducing the generation of Foxp3+ regulatory T cells (Tregs) (134)

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Structure of a human multidrug transporter in an inward-facing conformation

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Kidney toxicity was considerably less common in the magnesium-treated group (Yoshida 2014)

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