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This research has been reviewed by the Mayo Clinic Conflict of Interest Review Board and was conducted in compliance with the Mayo Clinics conflict of interest policies

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Table 2: Adverse Reactions Occurring in 20% of Patients in KEYNOTE-189 *Graded per NCI CTCAE version 4.03

Weekly heart rate and blood pressure checks during the first 812 weeks of combined therapy allow early detection of any sympathomimetic effects

Dosing Protocol Reference microgram doses from the Symlin label, converted to U-100 units at 2 mg/mL (20 mcg per unit)

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