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Tesamorelin, a 44-amino-acid GHRH analog, is FDA approved for HIV-related lipodystrophy and is of interest in orthopaedics due to its anabolic effects on lean body mass

Doses are usually low and delivered in short pulses or continuous infusion based on effect needed, which makes stimulation targeted and controllable compared to more general agents

Research Overview BPC-157 (Body Protection Compound-157) is a synthetic pentadecapeptide derived from a gastric protein complex

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Its effects on tendon healing appear mediated through increased expression of growth hormone receptor and upregulation of tendon-specific markers

Bone and wound healing Preclinical studies have also investigated fractures, wounds, blood supply and tissue repair