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It can be described as an imbalance in ROS generation and antioxidant defence leading to accumulation of ROS

Rastogi et al., 2021)

PYY3-36 is structurally similar to pancreatic polypeptide (PP)

Semin Nephrol 6:1221 Deore MS, Naqvi S, Kumar A, Flora S (2021) Alpha-lipoic acid protects co-exposure to lead and zinc oxide nanoparticles induced neuro, immuno and male reproductive toxicity in rats

In the setting of microbial infection, PAMPs derived from the invading microbes are recognized by pattern recognition receptors (PRRs) present in the cytosol or at the cell surface of macrophages and other innate immune cells

Nature 432, 10321036 (2004)