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Finally, the mitochondrial depletion of CoA-SH impairs -oxidation of fatty acids (and VPA) and ATP production

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(2003) Development 130 (2): 379-389)

NASH, nonalcoholic steatohepatitis

STOPPFrail is applicable in adults aged 65 or older who meet all the following criteria 37 : End-stage irreversible pathology Poor one year survival prognosis Severe functional or cognitive impairment or both Symptom control is priority rather than preventing disease progression Example criteria include 37 Avoid antiplatelets for primary cardiovascular prevention due to lack of evidence Bisphosphonates are unlikely to be beneficial for short-term osteoporosis treatment Aim for antidiabetic monotherapy with less stringent glycemic control (i.e., hemoglobin A1c goal of less than 8%) End-of-Life Care Prescribers and pharmacists should re-evaluate medications and minimize the pill burden for patients receiving palliative care, particularly at end-of-life (i.e., life expectancy of less than three months)