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Myeloid-mediated immunosuppression and stromal exclusion emerge as key actionable microenvironmental resistance axes, given that are particularly amenable to therapeutic intervention, supported by the clinical availability of VEGF-targeting agents, CSF1R inhibitors, and immunomodulatory combination strategies

doi: 10.1088/0957-4484/16/10/059 101 MullerM.MerrettN

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Thus, how to protect grafted islets without the long-term use of systemic immunosuppression has become a focused research area (117)

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LR3-IGF-1 bypasses the GH-axis and directly engages the IGF-1 receptor producing IGF-1-receptor effects without the broader pleiotropic GH effects