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As for the best treatment duration, in an open-label trial GlyNAC supplementation for 16-weeks or 24-weeks resulted in similar outcomes, while withdrawing GlyNAC for 12-weeks led to loss/decrease of benefits

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When autophagy is initiated, an isolated membrane structure called a phagophore is formed at a special region associated with the endoplasmic reticulum (ER), Golgi apparatus, and ERGolgi intermediate compartment 20,21,22