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While there are different models to study glutathione metabolism, in this study we used BSO as it is a specific and potent chemical inhibitor of the rate limiting enzyme GCLC (38)

10.1161/ATVBAHA.107.152298 [DOI] [PubMed] [Google Scholar] 23.Kazemi-Shirazi L, Endler G, Winkler S, et al

Phytochemistry 71 (5-6), 495501

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Of particular interest is the molecular classification of CRC, based on RNA expression patterns, yielding four consensus molecular subtypes (CMS1-4) [3]