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To solve the challenge, numerous researchers devote to exploring the mechanism of PIPN, which are principally implicated in transporter overexpression (Sprowl et al., 2013), ROS upregulation (Leo et al., 2020), ion channel dysfunction (Descoeur et al., 2011), transient receptor potential (TRP) overexpression (Chukyo et al., 2018), inflammatory response (Janes et al., 2015), and so on

In a study of 16 patients with chronic CIPN who were in remission and no longer receiving chemotherapy, 30-minute application of an 8% capsaicin patch to the feet resulted in lower patient-reported levels of pain, touch-evoked pain, and cold-evoked pain, with overall significant pain relief (Anand 2019)

doi: 10.1111/obr.13649 5 BridgemanSCNorthropWMeltonPEEllisonGCNewsholmePMamotteCDS

Hyperhomocysteinemia in Cardiovascular Diseases: Revisiting Observational Studies and Clinical Trials

Chen Fu, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers