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Giuliante et al

This is particularly relevant for oral administration, which is subject to intrinsic factor saturation and receptor limitations in the ileum (Paul and Brady, 2017

doi: 10.1091/mbc.12.8.2245

These effects collectively contribute to the immunomodulatory properties of Cbl, which raises the possibility that it could affect how the immune system reacts to autoimmune diseases such as MS [30,31,32]