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402 This influx is predominantly facilitated by Ca 2+ release-activated Ca 2+ (CRAC) channels embedded in the plasma membrane

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Abnormal enterocyte differentiation and increased enterocyte apoptosis due to the failure of the cells to maintain ionic balance and by increased production of interferon- (IFN) and TNF results in a reduction in the height of the villus and an increase in crypt depth [62]

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